Antiretroviral Drug Use in a Cohort of HIV-Uninfected Women in the United States: HIV Prevention Trials Network 064
Year: 2015
Type: article
Study design: Observational Study
Abstract: Antiretroviral (ARV) drug use was analyzed in HIV-uninfected women in an observational cohort study conducted in 10 urban and periurban communities in the United States with high rates of poverty and HIV infection. Plasma samples collected in 2009-2010 were tested for the presence of 16 ARV drugs. ARV drugs were detected in samples from 39 (2%) of 1,806 participants: 27/181 (15%) in Baltimore, MD and 12/179 (7%) in Bronx, NY. The ARV drugs detected included different combinations of non-nucleoside reverse transcriptase inhibitors and protease inhibitors (1-4 drugs/sample). These data were analyzed in the context of self-reported data on ARV drug use. None of the 39 women who had ARV drugs detected reported ARV drug use at any study visit. Further research is needed to evaluate ARV drug use by HIV-uninfected individuals.
Source: PLoS ONE
Authors: Iris Chen, William Clarke, San-San Ou, Mark A. Marzinke, Autumn Breaud, Lynda M. Emel, Jing Wang, James P. Hughes, Paul Richardson, Danielle F. Haley, Jonathan Lucas, Anne Rompalo, Jessica E. Justman, Sally L. Hodder, Susan H. Eshleman
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,382
Funders: U.S. Department of Health and Human Services, Bristol-Myers Squibb, Gilead Sciences, ViiV Healthcare, National Institutes of Health, National Institute of Mental Health, National Institute of General Medical Sciences, National Institute of Allergy and Infectious Diseases, Janssen Pharmaceuticals
Awards: G1310891712, G1714724206, G1739031488, Neighborhood Factors, Sexual Risk, and STIs in HIV-Infected and High-Risk Women, G5768112423, Cellular and Molecular Medicine, G9000072712, West Virginia Clinical and Translational Science Institute: A Statewide Organization Building Research Excellence and Engaging Communities to Improve Health, The Johns Hopkins Center for AIDS Research (JHU CFAR), Columbia Collaborative HIV/AIDS Clinical Trials Unit, SDMC: HIV Prevention Trials Network, G95499620, G95938990
OpenAlex ID: W2210986344