The birth of a deadly yeast: tracing the evolutionary emergence of virulence traits in Candida glabrata
Year: 2015
Type: review
Abstract: The yeast Candida glabrata is an opportunistic human fungal pathogen whose incidence has increased in the last two decades. Despite its name, this yeast is only distantly related to the model fungal pathogen C. albicans, and more closely related to Saccharomyces cerevisiae and other yeasts that underwent an ancient whole-genome duplication. Understanding what specific traits make C. glabrata a successful opportunistic pathogen within a clade of mostly innocuous yeasts, and how these compare to virulence traits in distant pathogens such as C. albicans is a focus of intense research. From an evolutionary perspective, uncovering how the ability to infect humans has emerged multiple, independent times in different lineages may reveal new disease mechanisms and provide us with the capacity to predict which genomic features in a clade may confer a higher potential to develop virulence against humans.
Source: FEMS Yeast Research
Authors: Toni Gabaldón, Laia Carreté
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $3,297
Awards: G1073650752, G177484282, G2001806450, G2228568422, G2420301095, G2507712556, G2628364946, G265847165, G2678857217, Evolutionary genomics of long, non-coding RNAs, G3207356259, G3345895242, G393177772, G4029025415, G4053127980, G4210997206, G434337789, G4611036307, From Omics to Patient: Improving Diagnostics of Pathogenic Yeasts, G4937468798, G496129201, G5518805754, G5655821971, G5702163051, G5997916591, G666340268, G682275100, G744900933, G7521148733, Molecular Mechanisms of Fungal Pathogen Host Interactions, G7868512380, G7984235579, G8512683158
OpenAlex ID: W2211508526