Theoretical Analyses and Simulations of Anticancer Drug Delivery
Year: 2004
Type: book-chapter
Abstract: Large amounts of data on tumor cell survival as a function of exposure to anticancer drugs, drug pharmacokinetics, drug distribution in the body, and other aspects of drug delivery and effectiveness are continually being generated. Cancer therapies are becoming increasingly complex, and it is now possible to choose the time schedule of drug delivery, the site of delivery, the size, lipophilicity, release kinetics and other properties of a carrier, and numerous other options. However, it is clearly impossible to perform sufficient animal experiments or clinical trials to determine the optimal choices of all these variables. Even for drugs that have been used for decades, doses and schedules are often based on past experience and medical tradition rather than on rational analysis. These circumstances suggest an increasing need for theoretical models of anticancer drug delivery. Such models can provide a framework for synthesizing and interpreting available experimental data, and a rational basis for optimizing therapies using existing drugs and for guiding development of new drugs.
Source: Humana Press eBooks
Authors: Ardith W. El-Kareh, Timothy W. Secomb
Language: English
Subfield: Modeling and Simulation
Field: Mathematics
Domain: Physical Sciences
Open Access status: hybrid
OpenAlex ID: W2212864153