Work

The Prodrug Approach: A Successful Tool for Improving Drug Solubility

Year: 2015

Type: review

Abstract: Prodrug design is a widely known molecular modification strategy that aims to optimize the physicochemical and pharmacological properties of drugs to improve their solubility and pharmacokinetic features and decrease their toxicity. A lack of solubility is one of the main obstacles to drug development. This review aims to describe recent advances in the improvement of solubility via the prodrug approach. The main chemical carriers and examples of successful strategies will be discussed, highlighting the advances of this field in the last ten years.

Source: Molecules

DOI: 10.3390/molecules21010042

Authors: Daniela Jornada, Guilherme Dos Santos Fernandes, Diego Chiba, Thais De Melo, Jean Dos Santos, Man Chung

Institution: Universidade Estadual Paulista (Unesp)

Language: English

Topic: Drug Solubulity and Delivery Systems

Subfield: Pharmaceutical Science

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,258