Year: 2010
Type: article
Abstract: The carcinoembryonic antigen related cell adhesion molecule (CEACAM) family of proteins is involved in insulin signaling, lipogenesis, immunity, and tumor suppression.To identify a function for CEACAM2, we created a murine model without expression of the Ceacam2 gene.We report that the male Ceacam2 knockout mice are overall insulin sensitive.This occurs in light of hyperphagia and insulin resistance in skeletal muscle.Sensitivity is likely due to increased energy expenditure and to higher rates of insulin secretion.CEACAM2 localization to the ventromedial hypothalamus suggests a role for CEACAM2 in central regulation of energy balance and peripheral insulin action and secretion.To the people who taught me first, and from whom I continue to learn each day.Your boundless strength supports me and helps me overcome obstacles far less daunting than the ones you have faced fearlessly.Your overwhelming generosity-for you always give in any and every way you can-sustains me.To the people to matter most, Aruna and Ramesh Patel.I could not have done it without you.
Author: Payal R. Patel
Institution: University of Toledo
Language: English
Subfield: Endocrine and Autonomic Systems
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2214259113