Work

Shared Intelligence: A Patient-Derived, Deeply Characterized Glioblastoma Cell Line Resource

Year: 2015

Type: article

Abstract: The highly lethal brain cancer glioblastoma (GBM) is one of the most genomically well-characterized forms of cancer. Mutations in coding genes that occur at frequencies greater than 5% above background are likely to have already been identified (Lawrence et al., 2014), revealing a landscape of potentially actionable drug targets. Growth factor receptor amplification and mutations, including epidermal growth factor receptor (EGFR) alterations, PIK3CA mutations and PTEN deletion and mutation are especially common (Brennan et al., 2013).

Source: EBioMedicine

DOI: 10.1016/j.ebiom.2015.09.033

Authors: Genaro R. Villa, Paul S. Mischel

Institutions: University of California, Los Angeles, Ludwig Cancer Research, University of California San Diego, Moores Cancer Center

Language: English

Topic: Glioma Diagnosis and Treatment

Subfield: Genetics

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $5,780