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Rapid Antiretroviral Therapy Initiation for Women in an HIV-1 Prevention Clinical Trial Experiencing Primary HIV-1 Infection during Pregnancy or Breastfeeding

Year: 2015

Type: article

Abstract: During an HIV-1 prevention clinical trial in East Africa, we observed 16 cases of primary HIV-1 infection in women coincident with pregnancy or breastfeeding. Nine of eleven pregnant women initiated rapid combination antiretroviral therapy (ART), despite having CD4 counts exceeding national criteria for ART initiation; breastfeeding women initiated ART or replacement feeding. Rapid ART initiation during primary HIV-1 infection during pregnancy and breastfeeding is feasible in this setting.

Source: PLoS ONE

DOI: 10.1371/journal.pone.0140773

Authors: Susan Morrison, Grace John-Stewart, John J. Egessa, Sezi Mubezi, Sylvia Kusemererwa, Dennis K. Bii, Nulu Bulya, Francis Mugume, James D. Campbell, Jonathan Wangisi, Elizabeth A. Bukusi, Connie Celum, Jared M. Baeten, Partners PrEP Study Team

Institutions: University of Washington, The AIDS Support Organization, Infectious Diseases Institute, Makerere University, Kenya Medical Research Institute, Centers for Disease Control and Prevention

Language: English

Topic: HIV/AIDS Research and Interventions

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,382

Funders: Bill and Melinda Gates Foundation, University of Washington, Eunice Kennedy Shriver National Institute of Child Health and Human Development

Awards: Pediatric HIV-1 in Africa: Pathogenesis and Management, University of Washington Foundation - to conduct a placebo-controlled proof-of-concept phase III trial of the safety and efficacy of TDF and FTC/TDF in reducing HIV acquisition among HI...

OpenAlex ID: W2216267366

FWCI:

Cites: 6

Cited by: 6

Related to: 10