Work

Cell killing and DNA damage by hydrogen peroxide are mediated by intracellular iron

Year: 1984

Type: article

Abstract: Phenanthroline, a strong iron chelator, prevents both the formation of DNA single-strand breaks and the killing of mouse cells produced by H2O2. These results, taken together with our previous findings, indicate that the DNA damage is produced by hydroxyl radicals formed when H2O2 reacts with chromatin-bound Fe2+ and that this damage is responsible for the killing effect.

Source: Biochemical Journal

DOI: 10.1042/bj2180273

Authors: A C Mello Filho, M E Hoffmann, R Meneghini

Institutions: Universidade de São Paulo, Universidade Estadual de Campinas (UNICAMP)

Language: English

Topic: Redox biology and oxidative stress

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

Funders: Fundação de Amparo à Pesquisa do Estado de São Paulo, Conselho Nacional de Desenvolvimento Científico e Tecnológico, Financiadora de Estudos e Projetos

OpenAlex ID: W2216471839