Work

The extent of metalloproteinase-mediated LAG3 cleavage limits the efficacy of PD1 blockade

Year: 2015

Type: article

Abstract: Meeting abstracts Inhibitory receptors control immune responses preventing exacerbated T cell activation and the onset of autoimmunity; however, they also limit antitumor immunity. Enhanced co-expression of PD1 and LAG3 phenotypically mark functionally exhausted tumor-specific T cells, with dual

Source: Journal for ImmunoTherapy of Cancer

DOI: 10.1186/2051-1426-3-s2-p216

Authors: Lawrence P Andrews, Andrea L Szymczak-Workman, Creg J Workman, Dario AA Vignali

Institution: University of Pittsburgh

Language: English

Topic: Cancer Immunotherapy and Biomarkers

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,490