Year: 2014
Type: article
Abstract: At the time when KLF8 was cloned as a FAK-induced gene, nothing but a partial mRNA sequence of it was known. During the study into the role of KLF8 in FAK-promoted cell cycle progression [1], we noticed that KLF8 expression is upregulated in some human cancer cell lines particularly breast and ovarian cancer types as demonstrated by the Stanford University cDNA microarray database for the NCI-60 human cancer cell line panel. Meanwhile, we also obtained unpublished data showing that ectopic overexpression of KLF8 prolongs survival of various cell types in nutrient-deprived or over-consumed medium. These observations pointed to a potential role of KLF8 in cancer.
Source: Oncoscience
Author: Jihe Zhao
Institution: University of Central Florida
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: bronze
Funder: National Cancer Institute
OpenAlex ID: W2216821029