Relationship between adiponectin receptor 1 gene polymorphisms and ischemic stroke.
Year: 2015
Type: article
Study design: Observational Study
Abstract: OBJECTIVE: Previous study suggested adiponectin receptor 2 (ADIPOR2) genetic polymorphisms were associated with the risk of ischemic stroke. However, the relation between adiponectin receptor 1 (ADIPOR1) gene polymorphism and stroke remains unclear. METHODS: In the present study, we utilized the polymerase chain reaction-sequencing method to detect rs2275737 and s1342387 genotypes of ADIPOR1 gene in 300 cases of ischemic stroke patients and 300 age- and sex- matched healthy controls. RESULTS: For rs2275737, we found A allele carriers have increased risk to ischemic stroke (OR=2.570, 95% CI: 1.999-3.305); also, we found rs1342387 A allele was associated with the risk for stroke (OR=1.351, 95% CI: 1.074-1.699). After adjusted for confounders such as hypertension, diabetes, and smoking, we found the association remains significant. CONCLUSION: ADIPOR1 genetic polymorphism may increase the risk of ischemic stroke.
Source: PubMed
Authors: Qian Han, Zunhua Shu, Xuemei Liang, Rui Mi, Lei Yang, Peng Li
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2216939304