Work

Clinical Utility of Laboratory Detection of Clostridium difficile Strain BI/NAP1/027

Year: 2015

Type: review

Abstract: Clostridium difficile strain BI/NAP1/027 is associated with increased C. difficile infection (CDI) rates and severity, and the efficacy of some CDI therapies may be strain dependent. Although cultured C. difficile isolates can be reliably subtyped by various methods, the long turnaround times, high cost, and limited availability of strain typing preclude their routine use. Nucleic acid amplification tests identify BI/NAP1/027 rapidly from stool, but the emergence of closely related strains compromises test specificity. Although detection of epidemiologically significant pathogens is generally useful for infection control programs, specific data supporting use of rapid detection of BI/NAP1/027 as an infection control tool are still awaited.

Source: Journal of Clinical Microbiology

DOI: 10.1128/jcm.02340-15

Authors: Larry K. Kociolek, Dale N. Gerding

Institutions: Northwestern University, Lurie Children's Hospital, Loyola University Chicago, Edward Hines, Jr. VA Hospital

Language: English

Topic: Clostridium difficile and Clostridium perfringens research

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2217750679