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Hepatotoxicity of eugenol.

Year: 1994

Type: article

Abstract: EUGENOL a widely used pharmaceutical agent proceeds toxicity on inhalation in rats. Two different doses 20 & 30 μg/100g body weight/ day of eugenol were given intramuscularly to male albino rats for 10 days and the liver function was assessed by measuring the specific enzyme activities, and total and differential bilirubin concentration. There was an appreciable increase in total as well as differential bilirubin fractions and a dose dependent increase was noticed in the activities of alkaline phosphatase, transminases, lactate dehyrogenase with a decrease in the activity of glytamyl transferase activity, and suggesting eugenol to have a toxic effect on liver.

Source: PubMed Central

Authors: V Soundran, T Namagiri, S Manonayaki, G Vanithakumari

Institution: PSG Institute of Medical Sciences & Research

Language: English

Topic: Drug-Induced Hepatotoxicity and Protection

Subfield: Pharmacology

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2217900709

FWCI:

Cites:

Cited by: 11

Related to: 10