Suppression of Cytosolic NADPH Pool by Thionicotinamide Increases Oxidative Stress and Synergizes with Chemotherapy
Work
Year: 2015
Type: article
Abstract: NAD<sup>+</sup> kinase (NADK) is the only known cytosolic enzyme that converts NAD<sup>+</sup> to NADP<sup>+</sup>, which is subsequently reduced to NADPH. The demand for NADPH in cancer cells is elev... more
Source: Molecular Pharmacology
Authors Philip M. Tedeschi, Hongxia Lin, Murugesan Gounder, John E. Kerrigan, Emine Ercikan Abali +2 more
Institution Rutgers, The State University of New Jersey
Cites: 37
Cited by: 35
Related to: 10
FWCI: 0.767
Citation percentile (by year/subfield): 87.51
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: bronze