Work

A naphthalimide derived fluorescent sensor for solid-phase screening of cucurbit[7]uril–guest interactions

Year: 2015

Type: article

Abstract: A naphthalimide based fluorescent sensor displaying a significant increase in emission upon binding CB[7] with notable pH stability was developed and utilized in a surface-bound displacement assay for the rapid detection of CB[7] encapsulation of therapeutically relevant drug classes. Previously unknown binders with moderate to strong affinities were discovered.

Source: Chemical Communications

DOI: 10.1039/c5cc08350h

Authors: Gyan Hari Aryal, Cooper Hawkins Battle, Tod A. Grusenmeyer, Mengyuan Zhu, Janarthanan Jayawickramarajah

Institution: Tulane University

Language: English

Topic: Supramolecular Chemistry and Complexes

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: National Science Foundation, National Institutes of Health, National Institute of General Medical Sciences

Awards: A Supramolecular Chemistry Approach to Precisely Controlled Multi-Porphyrin Arrays in Water, Supramolecular Approaches to Protein Inhibitors Activated by MicroRNA-21