Work

Modeling the tumor microenvironment using chitosan-alginate scaffolds to control the stem-like state of glioblastoma cells

Year: 2015

Type: article

Abstract: Better prediction of in vivo drug efficacy using in vitro models should greatly improve in vivo success. Here we utilize 3D highly porous chitosan-alginate complex scaffolds to probe how various components of the glioblastoma microenvironment including extracellular matrix and stromal cells affect tumor cell stem-like state.

Source: Biomaterials Science

DOI: 10.1039/c5bm00514k

Authors: Forrest M. Kievit, Kui Wang, Ariane E. Erickson, Sheeny K. Lan Levengood, Richard G. Ellenbogen, Miqin Zhang

Institution: University of Washington

Language: English

Topic: 3D Printing in Biomedical Research

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Cancer Institute