Year: 2015
Type: article
Study design: Observational Study
Abstract: OBJECTIVES: We investigated the correlation between polygenic risk of ischemic stroke (and its subtypes) and cognitive ability in 3 relatively healthy Scottish cohorts: the Lothian Birth Cohort 1936 (LBC1936), the Lothian Birth Cohort 1921 (LBC1921), and Generation Scotland: Scottish Family Health Study (GS). METHODS: Polygenic risk scores for ischemic stroke were created in LBC1936 (n = 1005), LBC1921 (n = 517), and GS (n = 6,815) using genome-wide association study summary data from the METASTROKE collaboration. We investigated whether the polygenic risk scores correlate with cognitive ability in the 3 cohorts. RESULTS: In the largest cohort, GS, polygenic risk of all ischemic stroke, small vessel disease stroke, and large vessel disease stroke, but not cardioembolic stroke, were correlated with both fluid and crystallized cognitive abilities. The highest correlation was between a polygenic risk score for all ischemic stroke and general cognitive ability (r = -0.070, p = 1.95 × 10(-8)). Few correlations were identified in LBC1936 and LBC1921, but a meta-analysis of all 3 cohorts supported the correlation between polygenic risk of ischemic stroke and cognitive ability. CONCLUSIONS: The findings from this study indicate that even in the absence of stroke, being at high polygenic risk of ischemic stroke is associated with lower cognitive ability.
Source: Neurology
Authors: Sarah E. Harris, Rainer Malik, Riccardo Marioni, Archie Campbell, Sudha Seshadri, Bradford B. Worrall, Cathie L.M. Sudlow, Caroline Hayward, Mark E. Bastin, John M. Starr, David J. Porteous, Joanna M. Wardlaw, Ian J. Deary, Matthew Traylor, Martin Farrall, Elizabeth G Holliday, Jemma C Hopewell, Yu-Ching Cheng, Myriam Fornage, M Arfan Ikram, Steve Bevan, Alex P Reiner, Braxton D Mitchell, Robert Clarke, Giorgio B Boncoraglio, Pankaj Sharma, Joshua C Bis, Bruce M Psaty, Peter M Rothwell, Jonathan Rosand, James F Meschia, Kari Stefansson, Martin Dichgans, Unnur Thorsteinsdottir, Anita L DeStefano, Christopher Levi, Solveig Gretarsdottir, Peter Donnelly, Ines Barroso, Jenefer M Blackwell, Elvira Bramon, Matthew A Brown, Juan P Casas, Aiden Corvin, Panos Deloukas, Audrey Duncanson, Janusz Jankowski, Hugh S Markus, Christopher G Mathew, Colin NA Palmer, Robert Plomin, Anna Rautanen, Stephen J Sawcer, Richard C Trembath, Ananth C Viswanathan, Nicholas W Wood, Chris CA Spencer, Gavin Band, Celine Bellenguez, Colin Freeman, Garrett Hellenthal, Eleni Giannoulatou, Matti Pirinen, Richard Pearson, Amy Strange, Zhan Su, Damjan Vukcevic, Cordelia Langford, Sarah E Hunt, Sarah Edkins, Rhian Gwilliam, Hannah Blackburn, Suzannah J Bumpstead, Serge Dronov, Matthew Gillman, Emma Gray, Naomi Hammond, Alagurevathi Jayakumar, Owen T McCann, Jennifer Liddle, Simon C Potter, Radhi Ravindrarajah, Michelle Ricketts, Matthew Waller, Paul Weston, Sara Widaa, Pamela Whittaker
Institutions: Boston University, The University of Queensland, Western General Hospital, Alzheimer Scotland, Framingham Heart Study, Institute of Genetics and Cancer, MRC Human Genetics Unit, University of Virginia, University of Edinburgh, Institut für Schlaganfall- und Demenzforschung, Ludwig-Maximilians-Universität München
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: hybrid
Funders: Wellcome Trust, Scottish Government, National Institute for Health and Care Research, British Heart Foundation, Royal Society, Scottish Funding Council, University of Edinburgh, Centre for Cognitive Ageing and Cognitive Epidemiology, Stiftung zur Erforschung der Vaskulären Demenz, Directorate for Biological Sciences, Chief Scientist Office, Scottish Government Health and Social Care Directorate, Medical Research Council, Biotechnology and Biological Sciences Research Council, National Institute on Aging, National Institute of Neurological Disorders and Stroke
Awards: G1194337659, UC Davis Alzheimer's Disease Core Center, G1353455142, NIHR Senior Investigator Award, G232440474, Pharmacogenomic, genetic and trial-based studies of lipid-modifying therapies and vascular risk, G36433118, Improving prevention of stroke by better understanding of existing risk factors and treatments., G4641403149, G5067462658, G5218064391, A genome-wide association study of non-pathological cognitive ageing
OpenAlex ID: W2221817039