Work

Targeting the glucocorticoid receptor in breast and prostate cancers

Year: 2015

Type: article

Abstract: Steroid receptors for androgens and estrogens have essential roles in prostate and breast cancers. Recently, glucocorticoid receptor (GR) activity has also been proposed as having an important role in these cancers. Underscoring the cooperative nature of nuclear receptor activity, data now suggest that GR function in prostate and breast cancers is dependent on the tumor's concomitant androgen or estrogen receptor activity.

Source: Science Translational Medicine

DOI: 10.1126/scitranslmed.aac7531

Authors: Jacob Kach, Suzanne D. Conzen, Russell Z. Szmulewitz

Institution: University of Chicago

Language: English

Topic: Estrogen and related hormone effects

Subfield: Endocrinology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Cancer Institute