Neurobiological and genetic markers in schizophrenia: a theoretical replication using the Allen Institute for Brain Sciences online database
Year: 2012
Type: dissertation
Abstract: The Allen Institute for Brain Sciences Online Atlas Kristen Gallander Schizophrenia is a psychiatric disease that affects 1% of the human population, and is characterized as a strongly heritable neurodevelopmental disorder.Genome wide association studies have identified altered expression of dopamine-related genes such as Regulator of G-Protein Signaling 4 and Catechol-O-Methyltransferase to be linked with the occurrence of schizophrenia.Furthermore, altered neuronal organization and neural connectivity within the Dorsolateral Prefrontal Cortex has been associated with the disease, however no specific biomarker has been identified, and pathogenesis of the disease remains extremely obscure.The Allen Institute for Brain Science's Human Brain Atlas is an online resource that provided Colorimetric in situ hybridization and Nissl stained images, for the current analysis.The current study used the Human Brain Atlas to compare schizophrenic and control tissue specimen on the schizophrenia-linked characteristics: neuronal cell density, Catechol-O-Methlytransferase, and Regulator of G-Protein signaling 4 expression in the Dorsolateral Prefrontal Cortex.The current analysis hypothesized that there would be decreased RGS4, COMT and neuronal density within the DLPFC of patients with schizophrenia.It was also v
Author: Kristen Gallander
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2222655843