Year: 2013
Type: article
Study design: Observational Study
Abstract: To investigate chronic immune effects of polychlorinated biphenyl (PCB) and polychlorinated dibenzofuran (PCDF), autoantibodies including anti-Smith (Sm) antibody, anti-ribonucleoprotein (RNP) antibody, anti-centromere antibody and anti-double-stranded DNA (dsDNA) antibody, were studied in 168 patients with Yusho and 54 controls in 2012. Autoatibodies were present in some patients of Yusho; 1 case (0.6%) for anti-Sm antibody, 4 cases (2.4%) for anti-centromere antibody and 11 cases (6.5%) for anti-dsDNA antibody. However, these autoantibodies were not demonstrated in any controls. There was a significantly higher prevalence of elevated anti-centromere antibody in subjects with high PCB concentration than in those with low PCB concentration. We conclude that anti-centromere antibody is present in patients with Yusho, and it may be associated with blood PCB concentration.
Source: PubMed
DOI: 10.15017/26693
Author: Hiroshi Tsuji
Language: Japanese
Subfield: Rheumatology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2222800811