Year: 2015
Type: article
Abstract: The research roots of 19fluorine (19F) magnetic resonance imaging (MRI) date back over 35 years. Over that time span, 1H imaging flourished and was adopted worldwide with an endless array of applications and imaging approaches, making magnetic resonance an indispensable pillar of biomedical diagnostic imaging. For many years during this timeframe, 19F imaging research continued at a slow pace as the various attributes of the technique were explored. However, over the last decade and particularly the last several years, the pace and clinical relevance of 19F imaging has exploded. In part, this is due to advances in MRI instrumentation, 19F/1H coil designs, and ultrafast pulse sequence development for both preclinical and clinical scanners. These achievements, coupled with interest in the molecular imaging of anatomy and physiology, and combined with a cadre of innovative agents, have brought the concept of 19F into early clinical evaluation. In this review, we attempt to provide a slice of this rich history of research and development, with a particular focus on liquid perfluorocarbon compound-based agents.
Source: Engineering
Institutions: Washington University in St. Louis, Philips (Germany)
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,300
Awards: G132936425, G1383854014, Center for Multiple Myeloma Nanotherapy, Proteases in the Pathogenesis and Treatment of Thrombosis, G2100007707, G2181669537, G3117263138, Anti-Inflammatory Therapeutics for Cardiovascular Disease, Inhibition of NF-kB with siRNA/Peptide Nanoparticles for Arthritis Treatment, G4718251021, G7196538893, The Siteman Center of Cancer Nanotechnology Excellence *, G9000024588, G9000047431, G9000068874, G9000281211, G9000346793
OpenAlex ID: W2224005134