Comparison between CEA, CA 19-9 and CA 72-4 in Patients with Colon Cancer
Year: 2013
Type: article
Study design: Observational Study
Abstract: Background: In Egypt, colorectal cancer (CRC) is one of the most common malignancies and represents 6.5% of cancers. The most important currently available tumor markers in CRC that provide diagnostic information to reduce mortality and morbidity are carcinoembryonic-antigen (CEA), carbohydrate antigen 19-9 (CA19-9) and CA 72-4. The main objectives of the present work were to compare the serological tumor markers CEA, CA19-9 and CA 72-4 and to verify the effectiveness of each marker as a potential routine diagnostic test in CRC. Subjects and methods: Blood samples were collected from twenty five CRC patients then compared with thirty five normal blood samples from apparently healthy persons who were considered as controls. Serum of each sample was evaluated for the three tumor markers and assessed by ELISA technique Results: CA72-4 and CEA showed high statistically significant difference between CRC and controls, on the contrary CA19-9 showed a statistically insignificant between the studied groups. As for the results of the ROC curve, the sensitivity for using CA 72-4 parameter was 82.86%, the specificity was 100% and the highest AUC for CA72-4 denoting its performance as the preferred diagnostic routinetest among other markers mentioned above. Conclusions: Based on our findings, the results of this study indicated that the serum CEA is not a much more sensitive tumor marker than CA72-4. As well as the serum CA72-4 levels can be used in diagnosis of colon cancer and in need to be applied as a routine tumor marker. Keywords Colorectal cancer (CRC), Carcinoembryonic antigen (CEA),Cancer antigen 19-9 (CA 19-9), Cancer antigen 72-4 (CA72-4), Area undercurve (AUC)
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W2224251873