Copper-catalyzed intermolecular oxyamination of olefins using carboxylic acids andO-benzoylhydroxylamines
Year: 2016
Type: article
Abstract: This paper reports a novel approach for the direct and facile synthesis of 1,2-oxyamino moieties via an intermolecular copper-catalyzed oxyamination of olefins. This strategy utilizes O-benzoylhydroxylamines as an electrophilic amine source and carboxylic acids as a nucleophilic oxygen source to achieve a modular difunctionalization of olefins. The reaction proceeded in a regioselective manner with moderate to good yields, exhibiting a broad scope of carboxylic acid, amine, and olefin substrates.
DOI: 10.3762/bjoc.12.4
Authors: Brett N Hemric, Qiu Wang
Institution: Duke University
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: diamond
OpenAlex ID: W2224916178