Mediating medication adherence in renal transplant recipients: the roles of depressive symptoms and cognition
Year: 2009
Type: dissertation
Study design: Observational Study
Abstract: Cognitive abilities and depressive symptoms have been previously linked to medication adherence following renal transplantation.To further elucidate these relationships, we assessed two potential mediational models: 1) depressive symptoms mediate the relationship between cognition and adherence; and 2) cognition mediates the relationship between depressive symptoms and adherence.Renal transplant recipients (N=101) completed a cognitive battery, the CES-D, and the Transplant Effects Questionnaire (TxEQ).Using a productof-coefficients method, we compared the proposed models.Weaker cognitive performance was correlated with reduced adherence.Additionally, depressive symptoms (CES-D total score) and the CES-D Somatic Symptoms subscale, each partially mediated the relationship between cognition (PCA derived composite score) and TxEQ adherence scores.None of the other CES-D subscales were significant mediators.Conversely, cognition did not mediate the relationship between depressive symptoms and adherence.The CES-D Somatic Symptoms sub-scale (five questions) may have important utility as a predictor of medication adherence in renal transplant patients.
Source: Summit (Simon Fraser University)
Authors: Theone Paterson, Wendy Loken Thornton
Language: English
Subfield: Family Practice
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2226994599