Work

Spectrum of false positivity for the fourth generation human immunodeficiency virus diagnostic tests

Year: 2016

Type: article

Abstract: Novel fourth generation screening and confirmatory human immunodeficiency virus (HIV) assays are now commercially available and incorporated into new diagnostic algorithms. We report two cases involving a total of three patients which highlight the spectrum of false positivity for both the Abbott Architect p24 antigen/antibody assay and the confirmatory Multispot antibody differentiation test. We then discuss the mechanisms for false positivity and the associated clinical conditions or laboratory scenarios that may predispose to inaccurate interpretation.

Source: AIDS Research and Therapy

DOI: 10.1186/s12981-015-0086-3

Authors: Peter Liu, Patrick Jackson, Nathan Shaw, Scott Heysell

Institution: University of Virginia

Language: English

Topic: HIV Research and Treatment

Subfield: Virology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,990