(A) The addition of TL1A during naive T cell activation increases IL-2 production
Year: 2011
Type: other
Abstract: Naive CD4 T cells were stimulated with plate-bound anti-CD3/CD28 antibody under the indicated conditions. Culture supernatants were analyzed for IL-2 24 h later by ELISA. Data represent the mean of triplicate cultures, and error bars represent SD. Results are representative of three independent experiments with similar results. (B) TL1A regulates Th17 differentiation. Naive CD4 T cells were stimulated by plate-bound anti-CD3/CD28, in the presence of control Ig or 1 μg/ml Fc-TL1A, and under Th17-differentiating conditions in the absence or presence of anti–IL-2 antibodies. The percentages of IL-17– and IFN-γ–producing cells were measured by intracellular cytokine staining. Data are a representative of three independent experiments with similar results.Copyright information:Taken from "TL1A–DR3 interaction regulates Th17 cell function and Th17-mediated autoimmune disease"The Journal of Experimental Medicine 2008;205(5):1049-1062.Published online 12 May 2008PMCID:PMC2373838.
Source: Figshare
Authors: P. Pappu, Bhanu, Borodovsky, Anna, S. Zheng, Timothy, Yang, Xuexian, Wu, Ping, Dong, Xingwen, Weng, Shawn, Browning, Beth, L. Scott, Martin, Ma, Li, Su, Lihe, Tian, Qiang, Schneider, Pascal, A. Flavell, Richard, Dong, Chen, C. Burkly, Linda
Language: English
Topic: T-cell and B-cell Immunology
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W6939818144