Year: 2016
Type: review
Abstract: Bacterial meningitis is a devastating disease occurring worldwide with up to half of the survivors left with permanent neurological sequelae. Due to intrinsic properties of the meningeal pathogens and the host responses they induce, infection can cause relatively specific lesions and clinical syndromes that result from interference with the function of the affected nervous system tissue. Pathogenesis is based on complex host-pathogen interactions, some of which are specific for certain bacteria, whereas others are shared among different pathogens. In this review, we summarize the recent progress made in understanding the molecular and cellular events involved in these interactions. We focus on selected major pathogens, Streptococcus pneumonia, S. agalactiae (Group B Streptococcus), Neisseria meningitidis, and Escherichia coli K1, and also include a neglected zoonotic pathogen, Streptococcus suis. These neuroinvasive pathogens represent common themes of host-pathogen interactions, such as colonization and invasion of mucosal barriers, survival in the blood stream, entry into the central nervous system by translocation of the blood-brain and blood-cerebrospinal fluid barrier, and induction of meningeal inflammation, affecting pia mater, the arachnoid and subarachnoid spaces.
Source: Acta Neuropathologica
Institutions: San Diego State University, University of California San Diego, University of Veterinary Medicine Hannover, Foundation, Freie Universität Berlin, St. Jude Children's Research Hospital, Universitätsmedizin Göttingen, Evangelisches Krankenhaus Göttingen-Weende, University of Göttingen, University of Southern California, Children's Hospital Los Angeles, University of Würzburg
Language: English
Subfield: Microbiology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $2,823
Funders: Niedersächsisches Ministerium für Wissenschaft und Kultur, National Institutes of Health, U.S. Public Health Service, National Institute of Allergy and Infectious Diseases, National Institute of Neurological Disorders and Stroke, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Awards: Blood-brain barrier in bacterial meningitis, Brain Endothelial Cell Receptor for Escherichia coli, G4765216082, Role of Complement Proteins in E. coli Meningitis, Maneuvering of Macrophage Function By Escherichia coli K1, G8466299519, BRAIN ENDOTHELIAL GLYCOPROTEIN INTERACTIVE WITH E COLI, G9000008335
OpenAlex ID: W2228954012