Year: 2015
Type: review
Abstract: Cell reprogramming technologies have enabled the generation of various specific cell types including neurons from readily accessible patient cells, such as skin fibroblasts, providing an intriguing novel cell source for autologous cell transplantation. However, cell transplantation faces several difficult hurdles such as cell production and purification, long-term survival, and functional integration after transplantation. Recently, in vivo reprogramming, which makes use of endogenous cells for regeneration purpose, emerged as a new approach to circumvent cell transplantation. There has been evidence for in vivo reprogramming in the mouse pancreas, heart, and brain and spinal cord with various degrees of success. This mini review summarizes the latest developments presented in the first symposium on in vivo reprogramming glial cells into functional neurons in the brain and spinal cord, held at the 2014 annual meeting of the Society for Neuroscience in Washington, DC.
Source: eNeuro
Institutions: Pennsylvania State University, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Johannes Gutenberg University Mainz, University Medical Center of the Johannes Gutenberg University Mainz, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Lund University, The University of Texas Southwestern Medical Center
Language: English
Subfield: Developmental Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,925
Funders: Welch Foundation, Alzheimer's Association, New York Stem Cell Foundation, University of Pennsylvania, California Institute of Regenerative Medicine, Pennsylvania State University, National Institute for Health and Care Research, European Commission, Deutsche Forschungsgemeinschaft, Belgian Federal Science Policy Office, Vetenskapsrådet, National Institutes of Health, National Institute on Aging, National Institute of Mental Health, National Institute of Neurological Disorders and Stroke, FP7 Ideas: European Research Council
Awards: G1060237651, G1272256406, G1433018560, G1513346540, G1794584869, Reprogramming reactive glial cells into functional new neurons after SCI, GABAergic Synapse Assembly: Extrasynaptic GABAAR Targeting, G192932977, G2079692510, G2717434707, Induced neuronal cells: A novel tool to study neuropsychiatric diseases, G3207356259, G3673755145, G3696204176, G3890525546, Converting Alzheimer's reactive astrocytes into functional neurons, In Vivo Reprogramming of Glial Fate for Spinal Cord Repair, G4793289069, G5021035465, Molecular control of neurogenesis in the adult subventricular zone, G5728773876, G632656150, Probing Alzheimer synaptopathy in neurons derived from engineered human iPS cells, G7078904037, G724488324, In Vivo Regenerating Functional Neurons in Alzheimer's Model, Transcriptional Control of Adult Neural Stem Cells, G8344833554, G8472945693, IN VIVO REPROGRAMMING: A NOVEL ROUTE TO BRAIN REPAIR, G896728979, G9000289661
OpenAlex ID: W2229719284