Work

Biometric Modeling of Gene‐Environment Interplay: The Intersection of Theory and Method and Applications for Social Inequality

Year: 2015

Type: review

Abstract: For more than a decade, biometric moderation models have been used to examine whether genetic and environmental influences on individual differences might vary within the population. These quantitative Gene × Environment interaction models have the potential to elucidate not only when genetic and environmental influences on a phenotype might differ, but also why, as they provide an empirical test of several theoretical paradigms that serve as useful heuristics to explain etiology-diathesis-stress, bioecological, differential susceptibility, and social control. In the current article, we review how these developmental theories align with different patterns of findings from statistical models of gene-environment interplay. We then describe the extant empirical evidence, using work by our own research group and others, to lay out genetically informative plausible accounts of how phenotypes related to social inequality-physical health and cognition-might relate to these theoretical models.

Source: Journal of Personality

DOI: 10.1111/jopy.12231

Authors: Susan C. South, Nayla R. Hamdi, Robert F. Krueger

Institutions: Purdue University West Lafayette, University of Minnesota

Language: English

Topic: Genetic Associations and Epidemiology

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

Funder: National Institute on Aging

Awards: Integrative Pathways to Health and Illness, Integrative Pathways to Health and Illness