Preclinical Evaluation of Water-Soluble Coenzyme Q10 for Therapeutic Treatment of Parkinson's Disease
Year: 2012
Type: dissertation
Abstract: Parkinson's disease is a common neurodegenerative disorder resulting from progressive loss of dopaminergic neurons in the substantia nigra pars compacta region of the midbrain. Mitochondrial dysfunction and oxidative stress are major contributors to this disease. Currently there is no treatment to halt the progression of Parkinson's disease; there are only drugs for symptomatic relief. Previously, prophylactic treatment with a water-soluble formulation of coenzyme Q\n10 was shown to reduce the loss of dopaminergic neurons in the substantia nigra and ameliorate symptoms in a paraquat-induced rat model of Parkinson's disease. In this work, delivery of CoQ\n10 by the water-soluble formulation shows increased bioavailability in various rat tissues, including the brain. Also observed is a decrease in the loss of dopaminergic neurons in the substantia nigra by therapeutic water-soluble CoQ\n10 supplementation in a rat model. Hence, this formulation of CoQ\n10 may be used to slow or halt the progression of Parkinson's disease.
Author: Katie Facecchia
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2230796422