Year: 1987
Type: article
Abstract: HERAPY WITH CYCLOSPORINE (CsA) constitutes a major advance leading to the success of organ transplantation. 1 -3 CsA is a lipophilic drug and is poorly and variably absorbed in transplant patients.4 It is primarily eliminated from the body by hepatic metabolism.s Alterations in the hepatic function would therefore be expected to change the kinetics of CsA.We determined the effect of experimentally induced hepatic dysfunction on the pharmacokinetics of CsA in dogs.
Source: PubMed
Authors: S Takaya, I Zaghloul, S Iwatsuki, T E Starzl, T Noguchi, Y Ohmori, G J Burckart, R J Ptachcinski, R Venkataramanan
Institution: University of Pittsburgh
Language: English
Subfield: Pharmacology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2231674471