Work

Synthesis of Oxazocenones via Gold(I)-Catalyzed 8- Endo -Dig Hydroalkoxylation of Alkynamides

Year: 2015

Type: article

Abstract: Several benzoxazocenones have been found to exhibit novel cellular activities. In the present study, we report a gold(I)-catalyzed 8-endo-dig hydroalkoxylation reaction of alkynamides to access analogous oxazocenone scaffolds. This methodology provided an advanced intermediate, which was elaborated to a des-benzo analog of a bioactive benzoxazocenone.

Source: Organic Letters

DOI: 10.1021/ol503273v

Authors: Stephen S. Scully, Shao-Liang Zheng, Bridget K. Wagner, Stuart L. Schreiber

Institutions: Broad Institute, Howard Hughes Medical Institute, Harvard University, Harvard University Press

Language: English

Topic: Catalytic Alkyne Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,500