A nanocomposite of Au‐AgI core/shell dimer as a dual‐modality contrast agent for x‐ray computed tomography and photoacoustic imaging
Year: 2016
Type: article
Abstract: PURPOSE: To develop a core/shell nanodimer of gold (core) and silver iodine (shell) as a dual-modal contrast-enhancing agent for biomarker targeted x-ray computed tomography (CT) and photoacoustic imaging (PAI) applications. METHODS: The gold and silver iodine core/shell nanodimer (Au/AgICSD) was prepared by fusing together components of gold, silver, and iodine. The physicochemical properties of Au/AgICSD were then characterized using different optical and imaging techniques (e.g., HR- transmission electron microscope, scanning transmission electron microscope, x-ray photoelectron spectroscopy, energy-dispersive x-ray spectroscopy, Z-potential, and UV-vis). The CT and PAI contrast-enhancing effects were tested and then compared with a clinically used CT contrast agent and Au nanoparticles. To confer biocompatibility and the capability for efficient biomarker targeting, the surface of the Au/AgICSD nanodimer was modified with the amphiphilic diblock polymer and then functionalized with transferrin for targeting transferrin receptor that is overexpressed in various cancer cells. Cytotoxicity of the prepared Au/AgICSD nanodimer was also tested with both normal and cancer cell lines. RESULTS: The characterizations of prepared Au/AgI core/shell nanostructure confirmed the formation of Au/AgICSD nanodimers. Au/AgICSD nanodimer is stable in physiological conditions for in vivo applications. Au/AgICSD nanodimer exhibited higher contrast enhancement in both CT and PAI for dual-modality imaging. Moreover, transferrin functionalized Au/AgICSD nanodimer showed specific binding to the tumor cells that have a high level of expression of the transferrin receptor. CONCLUSIONS: The developed Au/AgICSD nanodimer can be used as a potential biomarker targeted dual-modal contrast agent for both or combined CT and PAI molecular imaging.
Source: Medical Physics
DOI: 10.1118/1.4939062
Authors: Anamaria Orza, Yi Yang, Ting Feng, Xueding Wang, Hui Wu, Yuancheng Li, Lily Yang, Xiangyang Tang, Hui Mao
Institutions: Emory University, University of Michigan, Michigan Medicine
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: bronze
Awards: Emory Molecular and Translational Imaging Center, MRI Capable Receptor Targeted Drug Delivery for Pancreatic Cancer, G2591766628, MR Investigation of IDH Mutation and Its Marker 2-HG in Brain Tumor Patients, G318930586, G3922278273, Stroma Breaking Theranostic Nanoparticle for Targeted Pancreatic Cancer Therapy, Theranostic Nano particles for Targeted Treatment of Pancreatic Cancer, G5850682332, G799801689, EARLY DETECTION OF AMYLOID PLAQUE IN ALZHEIMER'S DISEASE VIA X-RAY PHASE CT
OpenAlex ID: W2232385895