Work

Association of Oxygen Target and Growth Status With Increased Mortality in Small for Gestational Age Infants

Year: 2016

Type: article

Abstract: saturation group.It is known that SGA infants have higher mortality and worse outcomes compared with AGA infants of the same gestation.3 Furthermore, growth restriction has been shown to increase the risk of pulmonary hypertension in the setting of bronchopulmonary dysplasia.[4][5][6] These reports mirror our finding of bronchopulmonary dysplasia as a leading mortality cause in the SGA cohort.We view these analyses as hypothesis generating.These results must be confirmed in other oxygen targetting studies.An important opportunity to do this is in the planned Neonatal Oxygenation Prospective Meta-analysis, which includes data from 4800 infants with a prespecified analysis by growth status.We speculate that SGA infants may experience hypoxia in utero that destabilizes respiratory control or affects pulmonary vascular resistance, increasing vulnerability to lower saturation targets.

Source: Archives of Pediatrics and Adolescent Medicine

DOI: 10.1001/jamapediatrics.2015.3794

Authors: Michele C. Walsh, Juliann M. Di Fiore, Richard J. Martin, Marie Gantz, Waldemar A. Carlo, Neil Finer