Biomarkers of bacterial translocation in advanced chronic liver disease: the key to individualizing prognosis.
Year: 2016
Type: article
Abstract: Th e management of patients with liver cirrhosis has evolved signifi cantly in the past decade. No longer considered as having an invariably poor outcome, the need for better risk stratifi cation and prognostic models for this patient group has become increasingly apparent [1-3]. Th e defi nition and use of the term “cirrhosis ” per se is also under scrutiny, with the recent Baveno VI consensus guidelines suggesting that the term “advanced chronic liver disease ” (ACLD) should be used interchangeably [4]. Th is highlights the ongoing paradigm shift where advanced fi brosis and cirrhosis are perceived as two oft en clinically indistinguishable points on the same spectrum, with both attributing the risk of developing complications of chronic liver disease. Portal hypertension has long been recognized as the main pathophysiological process governing the prognosis of patients with ACLD. However, the development of clinical signs of
Source: Europe PMC (PubMed Central)
Authors: Avik Majumdar, Emmanuel Tsochatzis
Institutions: The Royal Free Hospital, University College London
Language: English
Subfield: Hepatology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2232857159