Year: 2015
Type: dissertation
Abstract: Alzheimer's disease (AD) is the most common form of dementia and it is characterized to be an age-related and progressive neurodegenerative disorder which main consequences are cognitive impairment and memory loss.The AD brain histological hallmarks are the formation of senile plaques , composed of Aβ peptides, and neurofibrillary tangles (NFTs), formed by hyperphosphorilated tau (pTau) protein.The origin of the disease still remains unclear but some hypothesis have been proposed.The first were the amyloid cascade and the tau protein hypothesis.Recent evidence suggest a hypothesis that consist of a metabolic disorder, which consider insulin resistance as a pathological key that leads to the other features of AD.Because of the role that insulin plays in T2DM, it set up a link between AD and T2DM suggesting that studying both disease in parallel would bring some new clues to discover the "lasts pieces of the puzzle".
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2233195939