Work

"Peak-tracking chip" (PTC) for bulk refractive index sensing and bioarray sensing

Year: 2013

Type: article

Abstract: Resonant techniques are of wide interest to detect variation of effective refractive index at a chip surface. Both Surface Plasmon Resonance (SPR) and dielectric resonant waveguide (RWGs) can be exploited. Through their design, RWGs allow more flexibility (size of the biomolecule to detect, detection angle...). Using specially designed RWG "Peak-tracking chip", we propose to use spatial information from a simple monochromatic picture as a new label-free bioarray technique. We discuss robustness, sensitivity, multiplex detection, fluidic integration of the technique and illustrate it through bulk refractive index sensing as well as specific recognition of DNA fragment from gyrase A.

Source: King Abdullah University of Science and Technology Repository (King Abdullah University of Science and Technology)

Authors: Kristelle Bougot-Robin, Robert H. Austin, H. Benisty, I‐Ming Hsing, Rimantas Kodzius, Shunbo Li, Weijia Wen, Yinghua Zhang

Language: English

Topic: Advanced Biosensing Techniques and Applications

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funder: Hong Kong University of Science and Technology

OpenAlex ID: W2233601299

FWCI:

Cites: 1

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Related to: 10