Work

Advancing translational research with next‐generation protein microarrays

Year: 2016

Type: review

Abstract: Protein microarrays are a high-throughput technology used increasingly in translational research, seeking to apply basic science findings to enhance human health. In addition to assessing protein levels, posttranslational modifications, and signaling pathways in patient samples, protein microarrays have aided in the identification of potential protein biomarkers of disease and infection. In this perspective, the different types of full-length protein microarrays that are used in translational research are reviewed. Specific studies employing these microarrays are presented to highlight their potential in finding solutions to real clinical problems. Finally, the criteria that should be considered when developing next-generation protein microarrays are provided.

Source: PROTEOMICS

DOI: 10.1002/pmic.201500374

Authors: Xiaobo Yu, Brianne Petritis, Joshua LaBaer

Institutions: Beijing Proteome Research Center, State Key Laboratory of Proteomics, Arizona State University

Language: English

Topic: Advanced Biosensing Techniques and Applications

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: National Cancer Institute