Molecular mechanisms of lymphangiogenesis: role of VEGFR-3 mediated signaling
Year: 2002
Type: dissertation
Abstract: 6 REVIEW OF THE LITERATURE 7 1. CELL SIGNALING BY RECEPTOR TYROSINE KINASES 7 1.1. RTK activation 7 1.2. Signal transduction 8 1.3. Signal down-regulation 9 2. DEVELOPMENT OF THE VASCULAR SYSTEM 10 2.1. Vasculogenesis and angiogenesis 10 2.2. Lymphangiogenesis 11 2.3. Phylogeny of blood and lymphatic vessels 12 2.4. Molecular identity of lymphatic versus blood vascular endothelial cells 13 3. MOLECULAR REGULATION OF VASCULAR DEVELOPMENT 14 3.1. Angiogenic and lymphangiogenic factors 14 3.1.1. VEGF family of growth factors 15 3.1.2. Angiopoietin family 17 3.2. Endothelial cell receptors 17 3.2.1. VEGF receptors 17 3.2.2. Tie receptors 19 3.2.3. Neuropilins 19 3.3. VEGFs and VEGFRs in the development of other organ systems 20 4. PATHOLOGIC CONDITIONS INVOLVING BLOOD AND LYMPHATIC VESSELS 21 4.1. Tumor development and progression 21 4.2. Lymphedema 22 AIMS OF THE STUDY 25 MATERIALS AND METHODS 26 RESULTS AND DISCUSSION 29 1. NEUROPILIN-1 IS A RECEPTOR FOR VEGF-B (I) 29 2. VEGFR-3 IS REQUIRED FOR THE DEVELOPMENT AND MAINTENANCE OF THE EMBRYONIC LYMPHATIC VASCULATURE (II) 30 3. VEGFR-3 TRANSDUCES LYMPHATIC ENDOTHELIAL CELL GROWTH, SURVIVAL AND MIGRATION SIGNALS (III)..... 32 3.1. Isolation of lymphatic endothelial cells 33 3.2. VEGFR-3 signal transduction 33 4. A GENETIC PROGRAM CONTROLLING THE LYMPHATIC VERSUS BLOOD VASCULAR ENDOTHELIAL CELL PHENOTYPE (IV) 34 4.1. Gene expression profiling of lymphatic and blood vascular endothelial cells 34 4.2. Adhesion molecules in lymphatic and blood vascular endothelial cells 35 4.3. Prox-1 as a fate determining factor for lymphatic endothelial cells 36 CONCLUDING REMARKS 37 ACKNOWLEDGEMENTS 38 REFERENCES 39
Source: Työväentutkimus Vuosikirja
Author: Taija Mäkinen
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2234566318