Variability in behaviour and arousal modulation in children with attention-deficit hyperactivity disorder : impact of environmental factors and circadian characteristics
Year: 2012
Type: dissertation
Abstract: Abbreviation listsuggestion shifts the primary focus of interest from dopaminergic (Levy, 1991) to noradrenergic deficits in ADHD.The idea that state-regulation deficits are, at least in part, related to noradrenergic LC dysfunction is confirmed by several treatment modalities in ADHD, which modulate deficits in noradrenergic pathways (see Berridge & Devilbiss, 2011;Biederman & Spencer, 1999;del Campo et al., 2011; for reviews on this topic).More detailed information on state-dysregulation processes and noradrenergic LC arousal dysfunction in ADHD is provided in chapter 7.Taken together, several ADHD models recognize an important influence of environmental conditions on the modulation of arousal levels and the expression of problem behaviour in ADHD.The validity of these theories has been confirmed in behavioural studies reporting that ADHD behaviour fluctuates according to different environmental factors such arousal (e.g., cognitive energetic deficits) are considered to be the result of dysregulated LC function.This model highlights the potential role of LC disruption in ADHD as a biological mediator of both context specific cognitive energetic effects and context independent circadian effects.Based on this perspective, specific recommendations for future research are presented.Finally, in chapter 8, we summarize our main findings, discuss their limitations and clinical implications, and propose some future research directions.
Author: Lindita Imeraj
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funder: Vlaamse regering
OpenAlex ID: W2235331352