Work

Kinins and kinin receptors in the pathogenesis of heart failure

Year: 2002
Type: dissertation
Abstract: 3H-BK tritium-labeled bradykinin ACE angiotensin-converting enzyme ACEi ACE inhibitor Ang II angiotensin II AP-1 activator protein 1 APM aminopeptidase M APP aminopeptidase P AT 1 angiotensin II type 1 receptors AT 2 angiotensin II type 2 receptors BCG mycobacterium bovis bacillus Calmette-Guerin vaccination BK bradykinin BK-1R bradykinin type 1 receptors BK-2R bradykinin type 2 receptors BK-2R-KO BK-2R knockout mouse BSA bovine serum albumin cAMP cyclic adenosin monophosphate cGMP cyclic guanosin monophosphate CHD coronary heart disease CHF congestive heart failure CK creatinine kinase CMC cardiomyocytes COX2 cyclo-oxygenase, type 2 CPM carboxypeptidase M CPN carboxypeptidase N CREB cAMP responsive element binding protein DOCA deoxycortisone-acetate (salt) E/A early rapid diastolic filling wave/late diastolic filling wave EC endothelial cells EDHF endothelium-derived hyperpolarizing factor EET epoxyeicosatrienoic acid EGF epidermal growth factor eNOS endothelial nitric oxide synthase eNOS-KO eNOS-knockout mouse ERK/ELK extracellular-signal regulated kinase FAP furanacryloyl-Phe FAPGG furanacryloyl-Phe-Gly-Gly GAPDH glyceraldehyde-3-phosphate dehydrogenase GLUT4 glucose transporter protein 4 HF heart failure HMW kininogen high-molecular-weight kininogen HOE-140 BK-2R antagonist IDC idiopathic dilated cardiomyopathy IFN-γ interferon γ IKK2 IκB kinase 2 IL-1β interleukin 1β IL-6 Interleukin type 6 IL-8 Interleukin type 8 iNOS inducible nitric oxide synthase IP 3 inositol triphosphate IVS interventricular septum JAK Janus kinase KD kallidin KKK kininogen-kallikrein-kinin (system) KLK kallikrein LMW kininogen low-molecular-weight kininogen LPS lipopolysaccharide LVESD left ventricular end-systolic diameter LVEDD left ventricular end-diastolic diameter LVFS left ventricular shortening fraction LVH left ventricular hypertrophy MAP kinase mitogen-activated protein (kinase) MEK MAP kinase kinase MGEA DL-2-Mercaptomethyl-3-guanidino ethylthiopropanoic acid MI myocardial infarction mRNA messenger ribonucleic acid NEP neutral endopeptidase NEPi neutral endopeptidase inhibitor NF-κB nuclear factor-κB NO nitric oxide NPR-A natriuretic peptide receptor A Oct-1 octamer binding transcription factor I PBS phosphate buffered saline PC preconditioning PDGF platelet-derived growth factor PEA3 subfamily of Ets transcription factors PGE 2 prostaglandin E2 PGI 2 prostacyclin PI3K phosphoinositide 3 kinase Pif-1a PMA-inducible factor Ia PKC protein kinase C pKLK plasma kallikrein or prekallikrein, kallikrein B1 PLA 2 phospholipase A2 PLC phospholipase C PLD phospholipase D PW (thickness) posterior wall Raf-1 proto-oncogene serine/threonine-protein kinase (MAP kinase kinase kinase) RAS renin-angiotensin-aldosterone (system) RIA radioimmunoassay ROS reactive oxygen species RP-HPLC reverse-phase high-performance liquid chromatography RT-PCR reverse transcriptase-polymerase chain reaction SAPK stress-activated protein kinase SD rat Sprague-Dawley rat SDS-PAGE sodium-dodecyl-sulfate-polyacryl-amide gel SHR spontaneously hypertensive rat SMC smooth muscle cell SP I specificity protein I STAT signal transducer and activator of transcription STZ-rats rats with streptozotocin-induced diabetes TGF-β transforming growth factor β TIMP tissue inhibitor of matrix metalloproteinases tKLK tissue kallikrein, kallikrein 1, true kallikrein TNF-α tumor necrosis factor α tyk2 Janus kinase type tyrosine kinase of the JAK/STAT pathway VHD valvular heart disease WKY Wistar Kyoto rat
Language: English
Subfield: Hematology
Field: Medicine
Open Access status: green
OpenAlex ID: W2235647233
Cites: 618
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Related to: 10