Work

Cytokine therapy restores antitumor responses of NK cells rendered anergic in MHC I-deficient tumors

Year: 2015

Type: article

Abstract: Recent extraordinary advances in cancer immunotherapy rely primarily on marshaling T cell responses. Here we discuss how NK cell responses can be amplified. We find that MHC I-deficient tumors induce anergy of NK cells but that cytokine therapy restores NK cell activity and increases the survival of mice bearing MHC I-deficient tumors.

Source: OncoImmunology

DOI: 10.1080/2162402x.2014.1002725

Authors: Michele Ardolino, David H Raulet

Institution: University of California, Berkeley

Language: English

Topic: Immune Cell Function and Interaction

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,913