Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism
Year: 2016
Type: review
Abstract: The formation of SCFA is the result of a complex interplay between diet and the gut microbiota within the gut lumen environment. The discovery of receptors, across a range of cell and tissue types for which short chain fatty acids SCFA appear to be the natural ligands, has led to increased interest in SCFA as signaling molecules between the gut microbiota and the host. SCFA represent the major carbon flux from the diet through the gut microbiota to the host and evidence is emerging for a regulatory role of SCFA in local, intermediary and peripheral metabolism. However, a lack of well-designed and controlled human studies has hampered our understanding of the significance of SCFA in human metabolic health. This review aims to pull together recent findings on the role of SCFA in human metabolism to highlight the multi-faceted role of SCFA on different metabolic systems.
Source: Gut Microbes
Authors: Douglas J. Morrison, Tom Preston
Language: English
Topic: Gut microbiota and health
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,060
Awards: Using crop genetics to understand the importance of dietary resistant starches for maintaining healthy glucose homeostasis, Understanding the interplay between fermentable carbohydrate, colonic short chain fatty acid profile and gut hormone release, Increased Propionate Production In The Colon Is Associated With Reduced Appetite Body Weight And Improved Insulin Sensitivity, BBSRC DRINC Training Grant 2010, Regulating Appetite by Targeting Nutrient Delivery in the Gut, Manipulating the activity of the gut microbiota with fermentable carbohydrates to maximise the bioavailability of bioactive phenolic acids for health, NIHR Senior Investigator Award, Increased Propionate Production In The Colon Is Associated With Reduced Appetite Body Weight And Improved Insulin Sensitivity
OpenAlex ID: W2236332835