Work

The ESCRT machinery: new roles at new holes

Year: 2016

Type: review

Abstract: The ESCRT machinery drives a diverse collection of membrane remodeling events, including multivesicular body biogenesis, release of enveloped retroviruses and both reformation of the nuclear envelope and cytokinetic abscission during mitotic exit. These events share the requirement for a topologically equivalent membrane remodeling for their completion and the cells deployment of the ESCRT machinery in these different contexts highlights its functionality as a transposable membrane-fission machinery. Here, we will examine recent data describing ESCRT-III dependent membrane remodeling and explore new roles for the ESCRT-III complex at the nuclear envelope.

Source: Current Opinion in Cell Biology

DOI: 10.1016/j.ceb.2015.12.001

Authors: Y Olmos, JG Carlton

Institution: King's College London

Language: English

Topic: Cellular transport and secretion

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $3,769

Funders: Wellcome Trust, National Institute for Health and Care Research