Year: 2002
Type: article
Abstract: Prostatic cancer and benign prostatic hyperplasia (BPH) are the common prostate diseases found in American men over 50 years old.We evaluated the chemotherapeutic efficacy of racemic gossypol [GP (±)], an antifertility agent, on prostate cancer and the role of estrogen on canine BPH.GP (±) was shown to inhibit growth and metastasis of prostate cancer cells in the in vitro system.Effect of GP (±) on the growth of prostatic cancer cells may be mediated by inducing production of transforming growth factor-ß1 (TGFß1) in prostate cancer cells.TGFß1, in turn, can regulate the expression of cell cycle regulatory protein cyclin D1 that regulate cell cycle progression of prostate cancer cells.Gossypol (-) [GP (-)] and cottonseed oil, like GP (±), also exhibit similar antiproliferative effects on the prostatic cancer cells.Moreover, the inhibitory dose of GP (-) and cottonseed oil have a greater potency than that of GP (±).GP (±) was also shown to inhibit the O 2 consumption and CO 2 production in prostate cancer cells.This inhibition may relate to inhibiting mitochondrial succinic dehydrogenase activity in those cells.Recently, we isolated a novel subline of the MAT-LyLu cells isolated from metastasized lungs of MAT-LyLu bearing Copenhagen rats (MLL cell).MLL cells displayed more invasive properties than MAT-LyLu cell, while MLL cells possessed lower mRNA levels of nm23, a metastasis suppressor gene, than MAT-LyLu cells.Both MLL and MAT-LyLu cells were susceptible to GP (±), which induced a dose-dependent Dedicated to my parents, my wife and my daughter v
Author: Jiahua Jiang
Institution: The Ohio State University
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2237704363