Year: 2015
Type: article
Abstract: Protection of bioreactors from viruses and mycoplasma remains a challenge. While the risk of these contamina-tions is known, and several recent high profile cases have raised awareness of this risk, many bioreactors remain unprotected. Currently available technologies, such as high-temperature short-time treatment and ultraviolet light treatment, can be difficult to implement due to footprint, efficacy, and media compatibility issues. Size exclusion nanofiltration may be a more ideal technology for virus and mycoplasma protection, poten-tially offering advantages in robustness, scalability, small footprint, and media compatibility. However, current virus removal filters, designed for monoclonal antibody purification, are generally poorly suited for cell culture media processes due to the large
Source: BMC Proceedings
Authors: Kimberly Mann, Jon Royce, Christina Carbrello, Robert Smith, Rong-Rong Zhu, Yuanchun Zeng, Anne Leahy, Mary Priest, Ven Raman, Jayant S Nick Harrington, Scott Bliss, William Bryant, Nhung Nguyen, Soleil Le, Danielle DeCesaro, Jeremy Perreault, Philip Goddard, Joe Orlando, Kevin Rautio
Institution: MilliporeSigma (United States)
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,290
OpenAlex ID: W2238092268