Work

Critical Review

Year: 2015

Type: review

Abstract: Almost half of new HIV infections worldwide occur in women, and vaginal intercourse is the most common mode of transmission. Accumulating evidence suggests that depot medroxyprogesterone acetate may increase HIV transmission, but little is known about the underlying mechanisms. We propose that hypoestrogenism in depot medroxyprogesterone acetate may contribute to increased HIV transmission. We present supportive evidence and propose potential interventions to prevent or treat vaginal hypoestrogenism using vaginal estrogens.

Source: JAIDS Journal of Acquired Immune Deficiency Syndromes

DOI: 10.1097/qai.0000000000000805

Authors: Martha Hickey, Jennifer L. Marino, Gilda Tachedjian

Institutions: Royal Women's Hospital, Burnet Institute, The University of Melbourne, Peter Doherty Institute, Monash University

Language: English

Topic: HIV/AIDS Research and Interventions

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Burnet Institute, Medical Research Council, National Health and Medical Research Council