Work

Dynamic nuclear polarization of biocompatible 13 C-enriched carbonates for in vivo pH imaging

Year: 2016

Type: article

Abstract: A hyperpolarization technique using carbonate precursors of biocompatible molecules was found to yield high concentrations of hyperpolarized (13)C bicarbonate in solution. This approach enabled large signal gains for low-toxicity hyperpolarized (13)C pH imaging in a phantom and in vivo in a murine model of prostate cancer.

Source: Chemical Communications

DOI: 10.1039/c5cc09724j

Authors: D. E. Korenchan, R. R. Flavell, C. Baligand, R. Sriram, K. Neumann, S. Sukumar, H. VanBrocklin, D. B. Vigneron, D. M. Wilson, J. Kurhanewicz

Institutions: University of California, San Francisco, University of California, Berkeley

Language: English

Topic: Advanced NMR Techniques and Applications

Subfield: Spectroscopy

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funders: U.S. Department of Defense, National Institutes of Health, National Cancer Institute, National Institute of General Medical Sciences, National Institute of Biomedical Imaging and Bioengineering

Awards: G1600419044, G3536126341, Ascorbate-based biomarkers for predicting radiation response in prostate cancer, G419271604, Novel Hyperpolarized MR Markers of Advanced Prostate Cancer Therapy, G8004040983, Hyperpolarized MRI Technology Resource Center

OpenAlex ID: W2238702835

FWCI: 3.007

Cites: 31

Cited by: 41

Related to: 10