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Effects of lithium and valproate on DNA damage and oxidative stress markers in an animal model of mania

Year: 2007
Type: conference-abstract
Abstract: fntrmluction: Recem s tudies have suggested that oxidalive strcs.-sand D NA damage may play a role in l he pathophysiology of bipolar di.sorder (BD) .ln lhe presenl study, we investigated lhe effecls of lhe m< ><>d sta bilizers lithium (LI) and valproale (VAL) on amphetamine-induced oxidalive stres..'i and D N A damagc in an animal model of mania.Mctl>ods: ln the first modd, deSigned to mimié the management of acute mania (re versal modcl).adult male \Vis tar rats reccived d•amphetamine (AMPH) or saline for 14 days, and hetwocn lhe 8th and 14th day, rats were treated with LI, VAL o r saline.ln lhe soc.ond model, desib'TIC d to mimic lhe main tenance trealment (prevention mo<iel), rats were prelreated wilh LI, VAL or saline, and betwecn lhe 8th and 14th day, animais roce.ivedAMPH or
Authors: Andreazza, Ana Cristina, Frey, Benício Noronha, Stertz, Laura, Boeckel, Caroline Zanotto de, Ribeiro, Leticia Carina, Valvassori, Samira da Silva, Réus, Gislaine Zilli, Luz, G., Giasson, K., Salvador, Mirian, Gonçalves, C. A., Quevedo, João Luciano de, Kapczinski, Flávio Pereira
Language: English
Field: Medicine
Open Access status: green
OpenAlex ID: W2241544651
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