Siglec-G Is A Negative Regulator Of Nf-Kb Activation And Has Pivotal Roles In B-1 Cell Development And Resistance To Sepsis
Year: 2008
Type: article
Abstract: Since Siglec-G is expressed at various isoforms and since anti-Siglec-G antibodies were not available commercially, we used mice in which the GFP cDNA was knocked into Siglec-G locus to analyze activation of the gene.Using the GFP as a surrogate marker, we detected activation of the Siglec-G locus on a subset of hematopoietic stem cells and all stages of B-lineage cells starting from the Pre-pro/Pro B cells in the bone marrow.In the periphery, Siglec-G is abundantly expressed on B cells.Dendritic cells and myeloid cells also express Siglec-G, though at a lower level than that on B cells.Siglec-G expression levels, as indicated by GFP intensity, are similarly high on all subsets of B cells in the periphery.
Author: Cheng Ding
Institution: The Ohio State University
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2245200920